高通量測序與系統(tǒng)生物學(xué)研討會(huì)

時(shí)間：2009年12月9日
地點(diǎn)：中科院上海生科院生科大樓二樓報(bào)告廳（岳陽路320號）

近年來，高通量測序技術(shù)已廣泛應(yīng)用于生物學(xué)研究的各個(gè)領(lǐng)域，很多生物學(xué)問題都可以借助高通量DNA測序技術(shù)予以解決。目前，上海伯豪生物技術(shù)有限公司（簡稱SBC，上海生物芯片有限公司下屬CRO子公司）和國家人類基因組南方研究中心協(xié)作互助，先后建立了Roche 454技術(shù)平臺(tái), Illumina Solexa技術(shù)平臺(tái)和ABI SOLiD技術(shù)平臺(tái)，已擁有ABI SOLiD3（5臺(tái)）、Roche Genome Sequencer FLX（1臺(tái)）和Illumina Genome Analyzer IIx（1臺(tái)），從而迅速成長為華東地區(qū)最大的高通量測序中心。

2009年末，SBC正式對外推出“SBC高通量測序系統(tǒng)解決方案”，將新一代DNA測序技術(shù)與生物芯片技術(shù)相結(jié)合，協(xié)助廣大科研工作者以更低廉的價(jià)格，更全面、更深入地分析基因組、轉(zhuǎn)錄組及蛋白質(zhì)組的各項(xiàng)數(shù)據(jù)。力爭盡快將高通量測序技術(shù)及生物芯片技術(shù)成為廣泛使用的常規(guī)實(shí)驗(yàn)手段，從而為生物學(xué)研究領(lǐng)域帶來革命性的變革。

主持人: 肖華勝博士（上海伯豪生物技術(shù)有限公司常務(wù)副總裁/生物芯片上海國家工程研究中心執(zhí)行主任）

08:45-09:00 簽到及領(lǐng)取資料和午餐券（提供麥當(dāng)勞或肯德基套餐）

09:00-10:00 人基因組全外顯子捕獲+高通量深度測序 —Agilent SureSelect Exon Capture + ABI SOLiD技術(shù)

報(bào)告人： 楊曉楠博士（上海伯豪生物技術(shù)有限公司高通量測序平臺(tái)技術(shù)負(fù)責(zé)人）

10:00-11:00 Functional Mutation Detection on SOLiD: A Practical Guide

報(bào)告人：Dr. Jeffrey G. Reid (Assistant Professor, Applied Biosystem Inc.)

Abstract: With the recent rapid increases in sequence yield it is easier now more than ever to produce the raw sequence data required for building a whole personal genome. However, there are a number of computational challenges to be faced in building a list of functional variants from the raw sequence data. The purpose of this presentation is to provide some insights into this process from the perspective of population-based sequencing approaches, cancer sequencing of tumor/normal pairs, and the discovery of functional variants in high-penetrance genetic disorders. Practical solutions to real-world data production and analysis problems will be discussed.

11:00-12:00 Empower the Sequence Efficiency with Agilent SureSelect Target Enrichment System

報(bào)告人：Dr. Jian Li (Business Channel Manager, Agilent Technologies Inc.)

Abstract: Current generation DNA sequencers have revolutionized genomics research through dramatic increases in throughput and spiraling reduction in costs. However, the large throughput of next generation sequencers also present data analysis bottlenecks/challenges. Such challenges have motivated researchers to increasingly focus their sequencing efforts on genomic regions that matter most to their interests. Agilent’s SureSelect Target Enrichment System takes advantage of the exceptional fidelity in 200-mer oligonucleotides synthesis to custom-design genomic regions of interest for targeted capture through a user-friendly web-portal, eArray. The target enrichment system uses both on-array and in-solution phase methods that are uniquely suited to meet researchers’ throughput and automation needs. While the on-array method uses 60-mer DNA oligos to capture 750 kb to 1 Mb genomic regions, the solution-phase method uses 120-mer biotinylated RNAs to capture Mb to whole exon regions to further increase the sequence efficiency. Agilent’s Target Enrichment system is developed and optimized for SOLiD platform as well as other NGS platforms.

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