product information

background
 
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000;  Rapold et al. 1989).


immunogen
 
human fibrinogen CAA50740


antibody format
 



goat
polyclonal,

affinity purified,
liquid





quantity
 



1 mg






storage
 
2-8 °C.


tested applications
 
This antibody is suitable for all immunoassay applications.


related products
 

IMS06-038-312 | Fibrinogen | biotinylated antibody

IMS09-038-335 | Fibrinogen | labelled with fluorescein

additional information
 
To be added when available.

application information

recommended dilution
 
The optimal working dilution should be determined by the investigator.


expected | apparent MW
 
24 kDa


confirmed reactivity
 
human fibrinogen


predicted reactivity
 
chicken, mouse


not reactive in
 
no confirmed exceptions from predicted reactivity known in the moment


additional information
 

Affinity purified using solid phase human fibrinogen. Antibody concentration is > 4.5 mg/ml (E 1% at 280 nm = 13.0).

Antibody is supplied in 10 mM sodium phosphate, 0.15 M sodium chloride, pH 7.2. Contains 0.05% (w/v) sodium azide as preservative. Antibody purity is > 95% based on SDS-PAGE.

selected references
 
to be added when available

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