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product information
background
Complement component C4 consists of three polypeptide chains (alpha, molecular weight 95 kDa; beta, molecular weight 75 kDa and gamma, molecular weight 33 kDa) and is usually present in serum at 200-600 mg/L. It is a protein of the classical complement pathway. When activated by C1s, peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.
immunogen
full length native protein P0C0L4 purified from human plasma
antibody format
hen;
polyclonal;
affinity purified IgY in 0.15M sodium chloride, 0.02M sodium phosphate, 0.1% sodium azide, pH 7.2;
liquid
quantity
200 µl
storage
store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
tested applications
Western blot (WB)
related products
IMS02-032-303 | anti-Complement component C4
IMS01-031-305 | anti-Complement component C4c
IMS01-066-309 | anti-Complement factor H
additional information
affinity purified on human C4 agarose
Total IgY concentration for this antibody is 15 mg/ml
application information
recommended dilution
use at an assay dependent dilution (WB)
expected | apparent MW
193 kDa
confirmed reactivity
human
predicted reactivity
human
not reactive in
no confirmed exceptions from predicted reactivity known in the moment
additional information
prior to conjugation: Only one precipitin arc in immunodiffusion against normal human serum or human C4. Only one precipitin arc in immunoelectrophoresis against normal human serum or human C4. Specific against human C4 alpha and beta chains in electroblotting when tested against normal human serum.
selected references
to be added when available
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