Recombinant Human IL-36γ (IL-1F9)
產(chǎn)品編號:
200-36G
別名:
IL-1F, IL-1ε (epsilon), IL-1H1
描述:
The IL-1 family is
comprised of 11 structurally related ligands, including recently re-named IL-36
α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues
containing epithelial cells. IL-36γ
signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on
certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36
ligands induces dendritic cell maturation and activation. IL-36γ also functions
as an agonist of NF-kappaB, and can stimulate the inflammatory response in
bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein
containing 152 amino acid residues.
氨基酸序列:
SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND
來源:
E.coli
純度:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
生物活性:
Measured by its ability to induce IL-8 production by human PBMCs.
原產(chǎn)國:
USA
僅用于研究。不適用于診斷或治療。
