Recombinant Human IL-36β (IL-1F8)
產(chǎn)品編號(hào):
200-36B
別名:
IL-1F8 , IL-1H2, IL-1 eta
描述:
The IL-1 family is
comprised of 11 structurally related ligands, including recently re-named IL-36α
(IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in
various other tissues. IL-36β signals
through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain
dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands
induces dendritic cell maturation and activation. IL-36β also functions as an
agonist of NF-kappaB, and stimulates the production of pro-inflammatory
proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid
residues.
氨基酸序列:
MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNFYL DSVE
來(lái)源:
E.coli
純度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
Measured by its ability to induce IL-8 production by human PBMCs.
原產(chǎn)國(guó):
USA
僅用于研究。不適用于診斷或治療。
