Recombinant Human Gremlin-1
產(chǎn)品編號(hào):
120-42
別名:
CKTSF1B1, DAND2, DRM, IHG-2
描述:
Gremlin-1 (isoform-1) belongs
to a group of diffusible proteins which bind to ligands of the TGF-β family and
regulate their activity by inhibiting their access to signaling receptors. The
interplay between TGF-β ligands and their natural antagonists has major
biological significance during development processes, in which cellular
response can vary considerably depending upon the local concentration of the
signaling molecule. Gremlin is highly expressed in the small intestine, fetal
brain, and colon and lower expression in brain, prostate, pancreas and skeletal
muscle. Gremlin-1 regulates multiple functions in early development by
specifically binding to and inhibiting the function of BMP-2, -4, and -7.
It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant
Gremlin-1 is a 13.7 kDa protein
containing 160 amino acid residues.
氨基酸序列:
KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
來(lái)源:
CHO cells
純度:
Greater than 90% by SDS-PAGE gel and HPLC analyses.
生物活性:
Determined by its ability to inhibit BMP-4
induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is
0.07-0.11 μg/ml.
原產(chǎn)國(guó):
USA
僅用于研究。不適用于診斷或治療。
