Catalog Number:
120-39
Description:
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lung and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein. Recombinant human BMP-5 is a 15.6 kDa homodimeric disulfide-linked protein consisting of two identical 138 amino acid chains.
AA Sequence:
AANKRKNQNR NKSSSHQDSS RMSSVGDYNT SEQKQACKKH ELYVSFRDLG WQDWIIAPEG YAAFYCDGEC SFPLNAHMNA TNHAIVQTLV HLMFPDHVPK PCCAPTKLNA ISVLYFDDSS NVILKKYRNM VVRSCGCH
Source: CHO cells
Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
Research Interests:
Country of Origin:
USA
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PeproTech Inc. 創(chuàng)立于1988年,始終致力于為生命科學(xué)研究開發(fā)重組蛋白及相關(guān)產(chǎn)品,如今已成為能提供多種高質(zhì)量細(xì)胞因子和重組蛋白,相應(yīng)的單克隆、多克隆和生物素標(biāo)記抗體,以及ELISA試劑盒的世界領(lǐng)導(dǎo)者。PeproTech Inc.的產(chǎn)品涵蓋免疫調(diào)節(jié)蛋白、白介素、集落刺激因子、生長因子、化學(xué)趨化因子、干擾素、脂聯(lián)素、成纖維生長因子、轉(zhuǎn)化生長因子、腫瘤壞死因子、神經(jīng)營養(yǎng)素和防御素等諸多生命科學(xué)研究領(lǐng)域中重要的生物活性分子。
為跟蹤當(dāng)今科研發(fā)展、滿足日益增長的需求,PeproTech Inc.研制出無動(dòng)物成分的重組蛋白(animal-free recombinant proteins)。有效地避免了動(dòng)物源性污染引發(fā)潛在問題的可能性,從而可以應(yīng)用于臨床前研究和細(xì)胞治療。此外,PeproTech Inc.最新還開發(fā)出無動(dòng)物成分的培養(yǎng)基添加物試劑盒(animal-free Media Supplement Kits)。這些試劑盒經(jīng)改良設(shè)計(jì),其中的無血清組分對(duì)多種哺乳動(dòng)物細(xì)胞的生長有更好的維持能力。
PeproTech Inc.的產(chǎn)品自2000年進(jìn)入中國市場以來,以其優(yōu)良的品質(zhì)和合理的價(jià)格迅速得到國內(nèi)各重點(diǎn)研究和實(shí)驗(yàn)機(jī)構(gòu)的認(rèn)可和青睞。鑒于中國經(jīng)濟(jì)發(fā)展的良好態(tài)勢和中國生物醫(yī)藥研發(fā)投入的巨額增長,PeproTech Inc.于2009年10月在中國蘇州設(shè)立代表機(jī)構(gòu),意為中國的廣大用戶提供更好的支持和服務(wù),并助中國的科研和產(chǎn)業(yè)開發(fā)一臂之力。