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                                麻醉椒苦素
                                英文名稱(chēng):Methysticin總訪問(wèn):35
                                國(guó)產(chǎn)/進(jìn)口:進(jìn)口半年訪問(wèn):1
                                產(chǎn)地/品牌:美國(guó)/TargetMol產(chǎn)品類(lèi)別:生化試劑
                                規(guī)       格: 最后更新:2024-12-17
                                貨       號(hào):TQ0276
                                CAS   號(hào):20697-20-5
                                參考報(bào)價(jià):面議
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                                Product Introduction
                                Bioactivity


                                英文名: Methysticin

                                描述: Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.

                                體外活性: Methysticin triggers the most profound inducing effect on CYP1A1. Methysticin is able to activate the AhR signaling pathway. Hepa1c1c7 cells are treated with various concentrations of kava extract (0-50 μg/mL) and six kavalactones (0-100 μM) for 24 h. The results indicate that kava extract at concentrations up to 50 μg/mL and kavalactones up to 100 μM do not induce cell death. For the following studies, kava extract at 0.78-6.25 μg/mL and kavalactones at 0.78-25 μM, concentrations that cause no damage to cells, are used [1].

                                體內(nèi)活性: Methysticin (6 mg/kg) is administered once a week for a period of 6 months to 6-month-old transgenic APP/Psen1 mice by oral gavage. Methysticin treatment activates the Nrf2 pathway in the hippocampus and cortex of mice. The Aβ deposition in brains of Methysticin-treated APP/Psen1 mice is not altered compared to untreated mice. However, Methysticin treatment significantly reduces microgliosis, astrogliosis, and secretion of the pro-inflammatory cytokines TNF-α and IL-17A. Methysticin treatment results in significant activation of the Nrf2/ARE pathway in the hippocampus and the cortex but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice. Methysticin treatment significantly increases the expression of both genes compared to untreated animals [2].

                                存儲(chǔ)條件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

                                溶解度: Ethanol : 1 mg/mL (3.65 mM)
                                DMSO : 5 mg/mL (18.23 mM)


                                關(guān)鍵字: Methystici | Methysticin

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