Product Introduction
Bioactivity


英文名: Paricalcitol

描述: Paricalcitol 是一種 vitamin D receptor 激活劑，是一種 vitamin D 類似物，用于研究繼發(fā)性甲狀旁腺功能亢進(jìn)，該疾病與慢性腎功能衰竭有關(guān)。

動(dòng)物實(shí)驗(yàn): After TAC or sham surgery, a subset of the mice is treated with paricalcitol which activates the VDR, at a final dose of 300 ng/kg/day. Paricalcitol is dissolved in a 95% propylene glycol and 5% ethyl alcohol solution. Mice were intraperitoneally injected with paricalcitol (or vehicle only) three times per week on Monday, Wednesday, and Friday for five consecutive weeks. An established anti-hypertrophic and anti-fibrotic treatment, namely the angiotensin II receptor blocker (ARB) losartan is also included. Previous experiments have shown it is feasible and efficacious to dissolve losartan in the drinking water at a concentration of 30 mg/kg/day; mice are treated for five consecutive weeks. So, in total eight groups are studied. Sham (n=10), TAC (n=10), Sham + losartan (Sham-los, n=10), TAC + losartan (TAC-los, n=10), Sham + paricalcitol (Sham-pari, n=10), TAC + paricalcitol (TAC-pari, n=10), Sham + paricalcitol + losartan (Sham-combi, n=10) and TAC + paricalcitol + losartan (TAC-combi, n=10) [2].

體外活性: Paricalcitol (30 nM; HP + PC) produces a significant reduction in calcification relative to the observed in cells in HP medium. Paricalcitol causes a reduction in the levels of nuclear β-catenin to a level similar to that observed in control cells [1].

體內(nèi)活性: Paricalcitol (300 ng/kg/day) significantly decreases Tau and prevents LV dysfunction in mice. It reduces mRNA expression of ANP, fibronectin and collagen III in the TAC-pari mice [2].

存儲(chǔ)條件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : Insoluble
Ethanol : 12 mg/mL (38.8 mM)
DMSO : 95 mg/mL (228.02 mM)


關(guān)鍵字: Vitamin D receptor | Vitamin D | Inhibitor | VD/VDR | Paricalcitol | inhibit

相關(guān)庫(kù): Drug Repurposing Compound Library | Approved Drug Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Pediatric Drug Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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