Product Introduction
Bioactivity


英文名: 14-Deoxy-11,12-didehydroandrographolide

描述: 14-Deoxy-11,12-didehydroandrographolide (AP10) 是一種 Andrographolide 的類似物，能夠抑制 NF-κB 活性。

細胞實驗: A549 cells (3×10^3/well), BEAS-2B cells (5×10^3/well), and RBL-2H3 cells (3×10^3/well) are seeded in flat-bottomed 96-well plates overnight and then incubated with increasing concentrations (3-120 μM) of 14-deoxy-11,12-didehydroandrographolide for 24 and 48 h at 37°C. Cell viability is analyzed using the CellTiter 96 AQueous cell proliferation assay. Absorbance is recorded at 490 nm.

動物實驗: Female BALB/c mice, 6 to 8 weeks old, are sensitized and challenged with OVA. Briefly, mice are sensitized by ip injections of 20 μg of OVA and 4 mg of Al(OH)3 suspended in 0.1 mL of saline on days 0 and 14. On days 22, 23, and 24, mice are challenged with 1% OVA aerosol for 30 min. 14-deoxy-11,12-didehydroandrographolide (0.1, 0.5, and 1 mg/kg) or vehicle (1% DMSO) in 0.1 mL of saline is given by i.p injections 2 h before and 10 h after each OVA aerosol challenge.

體內活性: 14-Deoxy-11,12-didehydroandrographolide（1 mg/kg）在對甲基膽堿的反應中，顯著降低了卵清蛋白挑戰(zhàn)的小鼠的阻力，并恢復了Cdyn。

存儲條件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMF : 100 mg/mL (300.82 mM)


關鍵字: AP-10 | inhibit | Nuclear factor-κB | Inhibitor | 14 Deoxy 11,12 didehydroandrographolide | NF-κB | Nuclear factor-kappaB | 14Deoxy11,12didehydroandrographolide | AP 10 | 14-Deoxy-11,12-didehydroandrographolide

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