Product Introduction
Bioactivity


英文名: EIPA

描述: EIPA (L593754) 是一種有效的TRPP3 channel 抑制劑，IC50為 10.5 μM。EIPA 對(duì)Na+/H+交換 (NHE) 和巨噬細(xì)胞也有抑制作用。

細(xì)胞實(shí)驗(yàn): The effect of EIPA alone (without alanine or proline) is also examined in both control (DMEM cultured cells) and amino acid-starved cells. The cells are incubated for 6 h in DMEM containing 5% FBS and either 0 or 0.3 mM EIPA (labeled QNN and QNE, respectively), HBSS containing either 0 or 0.3 mM EIPA (labeled HNN and HNE, respectively), HBSS with 1.0 mM alanine (labeled HAN) or 0.5 mM proline (labeled HPN), HBSS with 1.0 mM alanine and 0.3 mM EIPA (labeled HAE), and HBSS with 0.5 mM proline and 0.3 mM EIPA (labeled HPE) [2].

體外活性: 研究發(fā)現(xiàn)，EIPA、benzamil和phenamil能快速且可逆地在-50 mV時(shí)阻斷Ca2+-激活的TRPP3通道激活，其IC50分別為143、10.5、1.1及0.14 μM[1]。與HAN和HPN組相比，EIPA處理后HAE和HPE組中自噬空泡的數(shù)量顯著增加。EIPA調(diào)控IEC-18細(xì)胞中與氨基酸相關(guān)的自噬啟動(dòng)及成熟過(guò)程[2]。此外，EIPA還能抑制cinnamoylphenazine (CA-PZ)和neutral red (NR)的攝取[3]。

存儲(chǔ)條件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 135 mg/mL (450.36 mM)


關(guān)鍵字: colon carcinoma | IEC-18 | NHE3 | renal failure | IBDs | Cation channel | ddY strain mice | MKN28 | L-593754 | Autophagy | gastric cancer | Inhibitor | neuron | pancreatic carcinoma | EIPA | inhibit | IECs | TRP Channel | L 593754 | Sodium-hydrogen Exchanger | Prostaglandin Receptor | Cyclooxygenase | COX | Na+/H+ Exchanger (NHE) | zinc | Transient receptor potential channels | calcium | kainite | Sodium/hydrogen Exchanger

相關(guān)產(chǎn)品: Orphenadrine hydrochloride | Benzocaine hydrochloride | Ropivacaine | SM-6586 | Flecainide acetate | Jingzhaotoxin-V | μ-TRTX-Hd1a | QX-222 chloride | PF 05089771 | GpTx-1

相關(guān)庫(kù): Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Sodium Channel Blocker Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compound Library

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