Product Introduction
Bioactivity


英文名: Prinaberel

描述: Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.

體外活性: Treatment with ERβ selective estrogen agonists liquiritigenin and ERB-041 reduced the ability to invade a reconstituted basement membrane and to migrate in response to the cellular stimulus [1]. Pretreatment the PMs with ERB-041 resulted in significant inhibition of LPS-induced iNOS expression and NF-kappaB activation by preventing its nuclear translocation [3].

體內(nèi)活性: Tumor numbers and volume were reduced by 60% and 84%, respectively, in the Erb-041-treated group as compared with UVB (alone) control. This inhibition in tumorigenesis was accompanied by a decrease in proliferating cell nuclear antigen (PCNA), cyclin D1, VEGF, and CD31, and an increase in apoptosis [2].

存儲條件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 38 mg/mL (140.1 mM)


關(guān)鍵字: Prinaberel | ERB041 | ERB-041

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