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Mycophenolic acid-13C17

CAS No. : 1202866-92-9

MCE 國(guó)際站：Mycophenolic acid-13C17

產(chǎn)品活性：Mycophenolic acid-¹³C₁₇ (Mycophenolate-¹³C₁₇) 是 ¹⁷C 標(biāo)記的 Mycophenolic acid (HY-B0421) 的同位素衍生物。Mycophenolic acid 是一種有效的非競(jìng)爭(zhēng)性肌苷單磷酸脫氫酶 (IMPDH) 抑制劑，EC₅₀ 為 0.24 μM。Mycophenolic acid 對(duì)多種 RNA 病毒具有抗病毒作用，包括流感 (influenza)。Mycophenolic acid 是一種免疫抑制劑。具有抗血管生成和抗腫瘤作用。

研究領(lǐng)域：Others  |  Anti-infection

作用靶點(diǎn)：Isotope-Labeled Compounds  |  Flavivirus

In Vitro: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus.
IMPDH is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides.
Mycophenolic acid (0.01-1 μM; 72 hours) exhibits preferential antiproliferative activity against the endothelial cells and fibroblasts. Endothelial cells are most sensitive cells to Mycophenolic acid treatment with an IC₅₀ <500 nM for antimitotic effects.
Fibroblasts are also prone to Mycophenolic acid-induced cell cycle inhibition but exhibit a higher IC₅₀ (<1 μM) compared with endothelial cells. The two human tumor cell lines A549 non-small cell lung cancer cells and PC3 prostate cancer cells show intermediate sensitivity with an IC₅₀ >1 μM. U87 glioblastoma cells are resistant against MPA treatment up to 1 μM.
Mycophenolic acid (0.05-2 μM; 18 hours) exhibits a dose-dependent down-regulation of HDAC2 and MYC, whereas up-regulates NDRG1.

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