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【產(chǎn)品名稱】
通用名稱：阿狄科®肌肉生長抑制素檢測試劑盒（酶聯(lián)免疫法）
英文名稱：Myostatin ELISA
【包裝規(guī)格】
96人份/盒
【預(yù)期用途】
用于定量測定人血清和血漿中的肌肉生長抑制素。僅供科研使用。
【背景知識】
肌肉生長抑制素屬于分泌型轉(zhuǎn)化生長因子 (TGF) 家族，是肌肉生長的負(fù)調(diào)節(jié)因子，然而，尚未詳細(xì)研究肌肉生長抑制素的確切作用（Roth 和 Walsh，2004）。
肌肉生長抑制素基因由 McPherron 等人于 1997 年引入。最早在老鼠身上發(fā)現(xiàn)和描述。肌肉生長抑制素基因有缺陷的小鼠比野生型動物表現(xiàn)出更強的肌肉生長。肌肉生長抑制素阻斷導(dǎo)致的肌肉量增加是由肥大（肌肉纖維厚度）和增生（纖維數(shù)量）的增加引起的。其他研究小組發(fā)現(xiàn)，自然繁殖的“比利時藍”中的肌肉生長抑制素基因失效-牛肉品種導(dǎo)致大量肌肉生長。
該基因現(xiàn)在也已在人類身上發(fā)現(xiàn)。據(jù)報道，肌肉無力的 HIV 感染男性（Gonzales-Cadavid 等 1998）、臥床不起的年輕男性（Zachwieja 等 1999）和肌肉萎縮的老年男性和女性（Yarasheski KE）中的肌生長抑制素免疫反應(yīng)性或表達升高等人，2002）。
Shi et al. (2007) 和其他研究人員發(fā)現(xiàn)，即使給小鼠喂食高脂肪飲食，肌肉生長抑制素缺乏也會抑制體內(nèi)脂肪生成。肌肉抑制素前肽的轉(zhuǎn)基因過表達，抑制肌肉生長抑制素信號傳導(dǎo)，減少高脂肪飲食中的體脂肪增加（Zhao 等人，2005）。肌肉生長抑制素信號傳導(dǎo)的類似抑制也與人體脂肪量的變化有關(guān)。Hittel 等人. (2010) 報告說，肌肉生長抑制素水平受適度健身訓(xùn)練的調(diào)節(jié)。此外，肌肉生長抑制素在因缺乏體力活動而獲得的胰島素抵抗的發(fā)展中起著因果作用。
研究領(lǐng)域：
2. Gonzalez-Cadavid, N.F. et al., 1998.Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.Pro-ceedings of the NationalAcademy of Sciences of the United States of America, 95(25),pp.14938-43.
3. Hamrick, M.W. et al., 2006. Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise.Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research, 21(3),pp.477-83.
4. McPherron, a C.& Lee, S.J.,1997.Double muscling in cattle due to mutations in the myostatin gene. Proceedings of the National Academy of Sciences of the UnitedStates of America,94(23), pp.12457-61.
5. Turner, C.H., 2000.Muscle-bone interactions, revisited.Bone,27(3), pp.339-40.
6. Yarasheski,K.E.et al.,2002.Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. The journal of nutriti-on, health & aging,6(5), pp.343-8.
7. Zachwieja,J.J.et al,1999.Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-doseT3 administration.Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology,6(2),pp.11-5.
8. Bowser,M. et al., 2013.Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. Experimental gerontology,48(2), pp.290-7.
9. Cheung, w.W.et al., 2008.Modulation of melanocortin signaling ameliorates uremic cachexia. Kidney international, 74(2), pp.180-6.
10.Diel, P.et al., 2010.Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle usinghighly sensitive immuno PCR. Molecular and cellular endocrinology，330(1-2),pp.1-9.
11.Ehehalt, S. et al., 2011.Investigation of myostatin serum levels before and after a 6-month lifestyle intervention program in obese children. Experimental and cli-nical endocrinology & diabetes : official journal, German Society of Endocrinologyland] German Diabetes Association, 119(4), pp.238-42.
12.Gruson, D.et al., 2011.Increased plasma myostatin in heart failure.European journal of heart failure,13(7), pp.734-6.
13.Hittel,D.S. et al.，2010. Myostatin decreases with aerobic exercise and associates with insulin resistance.Medicine and science in sports and exercise,42(11),pp.2023-9.
14.Kukreti, H.et al., 2013.Muscle-specific microRNA1(miR1) targets heat shock protein 70(HSP70) during dexamethasone-mediated atrophy.TheJournal of biologi-cal chemistry, 288(9), pp.6663-78.
15.Szulc, P. et al, 2012.Endocrine and clinical correlates of myostatin serum concentration in men--the STRAMBO study.The Journal of clinical endocrinology andmetabolism, 97(10), pp.3700-8.
16.Vamvini, M.T. et al., 2013. lrisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans.European journal of endocrino-logy / European Federation of Endocrine Societies,169(6), pp.829-34.
17.Wintgens, K.F. et al, 2012.Plasma myostatin measured by a competitive ELlSA using a highly specific antiserum.Clinica chimica acta; international journal of cli-nical chemistry,413(15-16), pp.1288-94.
18.Zamora, E. et al,2010.Serum myostatin levels in chronic heart failure.Revista espanola de cardiologia, 63(8), pp.992-6.
通用名稱：阿狄科®肌肉生長抑制素檢測試劑盒（酶聯(lián)免疫法）
英文名稱：Myostatin ELISA
【包裝規(guī)格】
96人份/盒
【預(yù)期用途】
用于定量測定人血清和血漿中的肌肉生長抑制素。僅供科研使用。
【背景知識】
肌肉生長抑制素屬于分泌型轉(zhuǎn)化生長因子 (TGF) 家族，是肌肉生長的負(fù)調(diào)節(jié)因子，然而，尚未詳細(xì)研究肌肉生長抑制素的確切作用（Roth 和 Walsh，2004）。
肌肉生長抑制素基因由 McPherron 等人于 1997 年引入。最早在老鼠身上發(fā)現(xiàn)和描述。肌肉生長抑制素基因有缺陷的小鼠比野生型動物表現(xiàn)出更強的肌肉生長。肌肉生長抑制素阻斷導(dǎo)致的肌肉量增加是由肥大（肌肉纖維厚度）和增生（纖維數(shù)量）的增加引起的。其他研究小組發(fā)現(xiàn)，自然繁殖的“比利時藍”中的肌肉生長抑制素基因失效-牛肉品種導(dǎo)致大量肌肉生長。
該基因現(xiàn)在也已在人類身上發(fā)現(xiàn)。據(jù)報道，肌肉無力的 HIV 感染男性（Gonzales-Cadavid 等 1998）、臥床不起的年輕男性（Zachwieja 等 1999）和肌肉萎縮的老年男性和女性（Yarasheski KE）中的肌生長抑制素免疫反應(yīng)性或表達升高等人，2002）。
Shi et al. (2007) 和其他研究人員發(fā)現(xiàn)，即使給小鼠喂食高脂肪飲食，肌肉生長抑制素缺乏也會抑制體內(nèi)脂肪生成。肌肉抑制素前肽的轉(zhuǎn)基因過表達，抑制肌肉生長抑制素信號傳導(dǎo)，減少高脂肪飲食中的體脂肪增加（Zhao 等人，2005）。肌肉生長抑制素信號傳導(dǎo)的類似抑制也與人體脂肪量的變化有關(guān)。Hittel 等人. (2010) 報告說，肌肉生長抑制素水平受適度健身訓(xùn)練的調(diào)節(jié)。此外，肌肉生長抑制素在因缺乏體力活動而獲得的胰島素抵抗的發(fā)展中起著因果作用。
研究領(lǐng)域：
- 肌肉生長的調(diào)節(jié)
- 肌肉萎縮
- 肌營養(yǎng)不良癥
- 獲得性胰島素抵抗
2. Gonzalez-Cadavid, N.F. et al., 1998.Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.Pro-ceedings of the NationalAcademy of Sciences of the United States of America, 95(25),pp.14938-43.
3. Hamrick, M.W. et al., 2006. Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise.Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research, 21(3),pp.477-83.
4. McPherron, a C.& Lee, S.J.,1997.Double muscling in cattle due to mutations in the myostatin gene. Proceedings of the National Academy of Sciences of the UnitedStates of America,94(23), pp.12457-61.
5. Turner, C.H., 2000.Muscle-bone interactions, revisited.Bone,27(3), pp.339-40.
6. Yarasheski,K.E.et al.,2002.Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. The journal of nutriti-on, health & aging,6(5), pp.343-8.
7. Zachwieja,J.J.et al,1999.Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-doseT3 administration.Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology,6(2),pp.11-5.
8. Bowser,M. et al., 2013.Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. Experimental gerontology,48(2), pp.290-7.
9. Cheung, w.W.et al., 2008.Modulation of melanocortin signaling ameliorates uremic cachexia. Kidney international, 74(2), pp.180-6.
10.Diel, P.et al., 2010.Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle usinghighly sensitive immuno PCR. Molecular and cellular endocrinology，330(1-2),pp.1-9.
11.Ehehalt, S. et al., 2011.Investigation of myostatin serum levels before and after a 6-month lifestyle intervention program in obese children. Experimental and cli-nical endocrinology & diabetes : official journal, German Society of Endocrinologyland] German Diabetes Association, 119(4), pp.238-42.
12.Gruson, D.et al., 2011.Increased plasma myostatin in heart failure.European journal of heart failure,13(7), pp.734-6.
13.Hittel,D.S. et al.，2010. Myostatin decreases with aerobic exercise and associates with insulin resistance.Medicine and science in sports and exercise,42(11),pp.2023-9.
14.Kukreti, H.et al., 2013.Muscle-specific microRNA1(miR1) targets heat shock protein 70(HSP70) during dexamethasone-mediated atrophy.TheJournal of biologi-cal chemistry, 288(9), pp.6663-78.
15.Szulc, P. et al, 2012.Endocrine and clinical correlates of myostatin serum concentration in men--the STRAMBO study.The Journal of clinical endocrinology andmetabolism, 97(10), pp.3700-8.
16.Vamvini, M.T. et al., 2013. lrisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans.European journal of endocrino-logy / European Federation of Endocrine Societies,169(6), pp.829-34.
17.Wintgens, K.F. et al, 2012.Plasma myostatin measured by a competitive ELlSA using a highly specific antiserum.Clinica chimica acta; international journal of cli-nical chemistry,413(15-16), pp.1288-94.
18.Zamora, E. et al,2010.Serum myostatin levels in chronic heart failure.Revista espanola de cardiologia, 63(8), pp.992-6.
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