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英文名稱 14-3-3 sigma (2E12)
中文名稱 14-3-3 sigm重組兔單克隆抗體
別 名 14 3 3 protein sigma; 14-3-3 protein sigma; 1433S_HUMAN; Epithelial cell marker protein 1; Er; HME 1; HME1; MGC143283; Mkrn3; Mme1; OTTHUMP00000004242; RP23 137L22.11; SFN; SFN protein; Stratifin; YWHAS.
研究領域 細胞生物 染色質(zhì)和核信號 神經(jīng)生物學 信號轉(zhuǎn)導 干細胞 轉(zhuǎn)錄調(diào)節(jié)因子
抗體來源 Rabbit
克隆類型 Monoclonal
克 隆 號 2E12
交叉反應 (predicted: Human, )
產(chǎn)品應用 WB=1:500-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
細胞定位 細胞核 細胞漿 分泌型蛋白
性 狀 Liquid
濃 度 1mg/ml
免 疫 原 recombinant human 14-3-3 sigma full length protein:
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
產(chǎn)品介紹 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibit
中文名稱 14-3-3 sigm重組兔單克隆抗體
別 名 14 3 3 protein sigma; 14-3-3 protein sigma; 1433S_HUMAN; Epithelial cell marker protein 1; Er; HME 1; HME1; MGC143283; Mkrn3; Mme1; OTTHUMP00000004242; RP23 137L22.11; SFN; SFN protein; Stratifin; YWHAS.
研究領域 細胞生物 染色質(zhì)和核信號 神經(jīng)生物學 信號轉(zhuǎn)導 干細胞 轉(zhuǎn)錄調(diào)節(jié)因子
抗體來源 Rabbit
克隆類型 Monoclonal
克 隆 號 2E12
交叉反應 (predicted: Human, )
產(chǎn)品應用 WB=1:500-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
細胞定位 細胞核 細胞漿 分泌型蛋白
性 狀 Liquid
濃 度 1mg/ml
免 疫 原 recombinant human 14-3-3 sigma full length protein:
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
產(chǎn)品介紹 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibit
試劑盒售后：本公司出售的試劑盒均保質(zhì)保量，質(zhì)量問題均可免費退換，另提供免費代測服務。
細胞售后：
1. 細胞運輸丟失、瓶身破損、培養(yǎng)液嚴重漏液等，重發(fā)；
3. 細胞收到當天以及第2,3天請拍照，未告知的視為產(chǎn)品合格。4-10天內(nèi)出現(xiàn)問題，請?zhí)峁┘毎掌图毎霈F(xiàn)問題的照片以及細胞相關(guān)操作的詳細步驟，并跟我公司人員及時溝通判定是否重發(fā)，具體可以參照我官網(wǎng)或者隨貨說明書相關(guān)售后條款。
細胞售后：
1. 細胞運輸丟失、瓶身破損、培養(yǎng)液嚴重漏液等，重發(fā)；
3. 細胞收到當天以及第2,3天請拍照，未告知的視為產(chǎn)品合格。4-10天內(nèi)出現(xiàn)問題，請?zhí)峁┘毎掌图毎霈F(xiàn)問題的照片以及細胞相關(guān)操作的詳細步驟，并跟我公司人員及時溝通判定是否重發(fā)，具體可以參照我官網(wǎng)或者隨貨說明書相關(guān)售后條款。
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