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CAS No. : 320-67-2

MCE 國際站：5-Azacytidine

產(chǎn)品活性：5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) 是胞苷核苷類似物，特異型抑制 DNA 甲基化。5-Azacytidine 與 DNA 結(jié)合共價(jià)捕獲 DNA甲基轉(zhuǎn)移酶 (DNA methyltransferases)，有益于逆轉(zhuǎn)表觀遺傳變化。5-Azacytidine 誘導(dǎo)細(xì)胞自噬 (autophagy)。

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Epigenetics  |  Autophagy

作用靶點(diǎn)：Nucleoside Antimetabolite/Analog  |  DNA Methyltransferase  |  Autophagy

In Vitro: Unmethylated CpG islands associated with a variety of genes become partially or fully methylated in tumors and can be reactivated by 5-Azacytidine. 5-Azacytidine acts as weak inducers of erythroid differentiation of Friend erythroleukemia cells in the same concentration range where they affect DNA methyltransferase activity. 5-Azacytidine inhibits L1210 cells with ID₅₀ and ID₉₀ values of 0.019 and circa 0.15 μg/mL, respectively.

In Vivo: TdR-³H incorporation is significantly inhibited when the animals are exposed to 5-Azacitidine (100 mg/kg, i.p.) for 2 hr or longer.

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