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Zoledronic acid 118072-93-8上海惠誠生物
英文名稱:Zoledronic acid總訪問:243
國產(chǎn)/進(jìn)口:進(jìn)口半年訪問:2
產(chǎn)地/品牌:Focus產(chǎn)品類別:標(biāo)準(zhǔn)品/對照品
規(guī)       格:25mg 最后更新:2024-12-30
貨       號:10-4512
CAS   號:118072-93-8
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Zoledronic acid ,CAS號:118072-93-8,分子式:C5H10N2O7P2,分子量:272.09 上;菡\生物現(xiàn)貨提供

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Cat. Number
10-4512
Chemical Name
[1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)
CAS Number
118072-93-8
Mol. Formula
C5H10N2O7P2
Mol. Weight
272.09
Qty 1
25mg
Qty 2
100mg
Appearance
White or off-white solid
Application Notes
98% by HPLC
Synonym
CGP 42446
Solubility
Soluble in Water (up to 2 mg/ml).
Storage condition
-20℃
Stability
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
References

Zoledronic acid (118072-93-8) is a potent inhibitor of bone resorption (IC50 = 2 nM in mouse calvarial cultures).1 The mechanism of its action is thought to be via inhibition of osteoclastic activity, induction of osteoclast apoptosis and blockage of osteoclastic resorption of mineralized bone and cartilage through its binding to bone. Zoledronic acid is a clinically useful drug for treatment of osteoporosis2, hypercalcemia of malignancy(HCM), multiple myeloma and bone metastases from solid tumors3. It has also been investigated as an antitumor agent and showing efficacy as an adjuvant therapy in several cancers.4,5

References/Citations
1) Green et al. (1994), Preclinical pharmacology of CGP 42446, a new, potent, heterocyclic bisphosphonate compound; J. Bone Miner. Res., 9 745
2) Deeks and Perry (2008) Zoledronic acid: a review of its use in the treatment of osteoporosis; Drugs Aging, 25 963
3) Perry and Figgitt (2004), Zoledronic acid: a review of its use in patients with advanced cancer; Drugs, 64 1197
4) Koto et al. (2010) Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis and shows combined effects with other anticancer agents; Oncol. Rep., 24 233
5) Tonyali et al. (2010) The role of zoledronic acid in the adjuvant treatment of breast cancer: current perspectives; Expert Opin. Pharmacother., 11 2715

 

Zoledronic acid ,貨號10-4512上;菡\提供25mg 100mg Zoledronic acid,美國focus原裝進(jìn)口,咨詢電話021-60498804
Zoledronic acid ,貨號10-4512上海惠誠提供25mg 100mg Zoledronic acid,美國focus原裝進(jìn)口,咨詢電話17715331663
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