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電話微信: 17715331663 QQ:2303607288
Cat. Number |
10-2618
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Chemical Name |
2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane
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CAS Number |
1675-54-3
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Mol. Formula |
C21H24O4
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Mol. Weight |
340.41
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Qty 1 |
10mg
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Qty 2 |
50mg
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Appearance |
White low melting point solid
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Application Notes |
95% by HPLC NMR (Conforms)
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Synonym |
Bisphenol A diglycidyl ether
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Solubility |
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml)
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Storage condition |
-20°C (des.)
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Stability |
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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References |
BADGE (1675-54-3) is a PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model1. Induces apoptosis via PPARγ-independent mechanisms2. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism3. Increases osteoblastogenesis and bone mass in a mouse model4. Active in vivo. References/Citations 1) Cuzzocrea et al. (2004), Rosiglitazone , a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation; Eur. J. Pharmacol., 483 79 BADGE ,貨號(hào)10-2618上;菡\提供10mg 50mg BADGE,美國focus原裝進(jìn)口,咨詢電話021-60498804
BADGE ,貨號(hào)10-2618上;菡\提供10mg 50mg BADGE,美國focus原裝進(jìn)口,咨詢電話17715331663
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