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阿西替尼 英文名:Axitinib ,CAS號(hào):319460-85-0,分子式:C22H18N4OS,分子量:386.47 上;菡\(chéng)生物現(xiàn)貨提供。
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Cat. Number |
10-2118
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Chemical Name |
阿西替尼 Axitinib
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CAS Number |
319460-85-0
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Mol. Formula |
C22H18N4OS
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Mol. Weight |
386.47
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Qty 1 |
10mg
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Qty 2 |
50mg
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Appearance |
White solid
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Application Notes |
99% by HPLC NMR (Conforms)
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Synonym |
N-Methyl-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
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Solubility |
Soluble in DMSO (up to 30 mg/ml)
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Storage condition |
-20°C (des.)
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Stability |
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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References |
Axitinib (319460-85-0) is a potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits BCR-ABL1 (T315I) with high potency, Ki = 149 pM for autophosphorylated ABL1 (T315I).3Inhibits proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Axitinib is a clinically useful anticancer agent.4 References/Citations 1) Hu-Lowe et al. (2008), Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1,2,3; Cancer Res., 14 7272 阿西替尼 英文名稱(chēng)Axitinib ,貨號(hào)10-2118上;菡\(chéng)提供10mg 50mg 阿西替尼 Axitinib,美國(guó)focus原裝進(jìn)口,咨詢(xún)電話(huà)021-60498804
阿西替尼 英文名稱(chēng)Axitinib ,貨號(hào)10-2118上海惠誠(chéng)提供10mg 50mg 阿西替尼 Axitinib,美國(guó)focus原裝進(jìn)口,咨詢(xún)電話(huà)17715331663
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