Withaferin A,CAS號(hào):5119-48-2,分子式:C28H38O6,分子量:470.60
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Cat. Number |
10-2114
|
Chemical Name |
Withaferin A
|
CAS Number |
5119-48-2
|
Mol. Formula |
C28H38O6
|
Mol. Weight |
470.60
|
Qty 1 |
1mg
|
Qty 2 |
5mg
|
Appearance |
White solid
|
Application Notes |
99% by HPLC NMR (Conforms)
|
Synonym |
(4β, 5β, 6β, 22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone
|
Solubility |
Soluble in DMSO (up to 20 mg/ml)
|
Storage condition |
-20°C (des.)
|
Stability |
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
|
References |
Displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro (IC50 = 12 nM) and in vivo.1 Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2 Covalently binds to the intermediate filament protein, vimentin3 inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in in vivo models.5
References/Citations
1) Mohan et al. (2004), Withaferin A is a potent inhibitor of angiogenesis; Angiogenesis, 7 115
2) Kaileh et al. (2007), Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with inhibition of its kinase activity; J. Biol. Chem., 282 4253
3) Bargagna-Mohan et al. (2007), The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin; Chem. Biol., 14 623
4) Thaiparambil et al. (2011), Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation; Int. J. Cancer, 129 2744
5) Livne-Bar et al. (2016), Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis; Cell Death Dis., 7 e2386
Withaferin A ,貨號(hào)10-2114上;菡\(chéng)提供1mg 5mg Withaferin A,美國(guó)focus原裝進(jìn)口,咨詢電話17715331663
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