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RI-1上;菡\生物415713-60-9
英文名稱:RI-1總訪問:452
國產(chǎn)/進口:進口半年訪問:1
產(chǎn)地/品牌:Focus產(chǎn)品類別:標準品/對照品
規(guī)       格:5mg 最后更新:2025-1-3
貨       號:10-1617
CAS   號:415713-60-9
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RI-1,CAS號:415713-60-9,分子式:C14H11Cl3N2O3,分子量:361.61 上;菡\生物現(xiàn)貨提供
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Cat. Number
10-1617
Chemical Name
RI-1
CAS Number
415713-60-9
Mol. Formula
C14H11Cl3N2O3
Mol. Weight
361.61
Qty 1
5mg
Qty 2
25mg
Appearance
Yellow solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
Solubility
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Storage condition
-20°C (des.)
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
References

RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.

References/Citations

1) Anand et al. (2017), Rad51-mediated double-strand break repair and mismatch correction of divergent substrates; Nature, 544 377 
2) Budke et al. (2012), RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells; Nucleic Acids Res., 40 7347
3) Balbous et al. (2016), A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells; BMC Cancer, 16 604
4) Berte et al. (2016), Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing response of Glioblastoma Cells Treated with Alkylating Drugs; Mol. Cancer Ther., 15 2665

RI-1 ,貨號10-1617上;菡\提供10mg 50mg RI-1,美國focus原裝進口,咨詢電話17715331663

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