SR-9009 ,CAS號(hào):1379686-30-2,分子式:C20H24CLN3O4S HCl,分子量:474.4
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Cat. Number |
10-1511
|
Chemical Name |
SR-9009
|
CAS Number |
1379686-30-2
|
Mol. Formula |
C20H24CLN3O4S HCl
|
Mol. Weight |
474.4
|
Qty 1 |
5mg
|
Qty 2 |
25mg
|
Appearance |
Tan solid
|
Application Notes |
98% by TLC
|
Synonym |
Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochloride
|
Solubility |
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
|
Storage condition |
-20℃
|
Stability |
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
|
References |
SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA1. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model2. SR-9009 suppresses atherosclerosis in a mouse model3. Specifically lethal to cancer cells and oncogene-induced senescent cells with no effect on the viability of normal cells or tissues.4 Disrupts pain associated with osteoarthritis by reducing BMAL1 expression in bmal1f/fNav1.8CreERT mice.5
References/Citations
1) Solt et al. (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists; Nature, 485 62
2) Li et al. (2014) A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury; Int.Immunopharmacol. 18 249
3) Sitaula et al. (2015) Suppression of atherosclerosis by synthetic REV-ERB agonist; Biochem. Biophys. Res. Commun., 460 566
4) Sulli et al. (2018) Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence; Nature, 553 351
5) Das et al. (2018) Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain; Gene 655 1
SR-9009 ,貨號(hào)10-1511上;菡\(chéng)提供5mg 25mg SR-9009,美國(guó)focus原裝進(jìn)口,咨詢(xún)電話17715331663
|
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