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Cat. Number |
10-1465
|
Chemical Name |
LH-846
|
CAS Number |
639052-78-1
|
Mol. Formula |
C16H13ClN2OS
|
Mol. Weight |
316.81
|
Qty 1 |
5mg
|
Qty 2 |
25mg
|
Appearance |
White solid
|
Application Notes |
98% by TLC NMR (Conforms)
|
Synonym |
N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneaceramide
|
Solubility |
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
|
Storage condition |
RT (des.)
|
Stability |
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
|
References |
LH-846 (639052-78-1) is a potent and selective inhibitor of casein kinase (CK) 1δ., IC50s=0.29, 1.3 and 2.5 μM for δ, ε and α isoforms respectively with no inhibition of CK2. Inhibits CK1δ-mediated phosphorylation and degradation of PER1 protein and lengthens circadian period in U2OS cells.1 References/Citations 1) Lee et al. (2011), A small molecule modulates circadian rhythms through phosphorylation of the period protein; Agnew Chem. Int. ed. Engl., 50 10608 LH-846 ,貨號(hào)10-1011 上;菡\(chéng)提供5mg 25mg LH-846,美國(guó)focus原裝進(jìn)口,咨詢電話17715331663 |