按品牌選擇
|
|
|||||||||||||||||||||||||||||||||
| [發(fā)表評(píng)論] [本類其他產(chǎn)品] [本類其他供應(yīng)商] [收藏] | ||||||||||||||||||||||||||||||||||
| 銷售商： 北京啟維益成科技有限公司 | 查看該公司所有產(chǎn)品 >> |
| Catalogue Number | CYT-334 |
| Synonyms | Soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE, TNF-related activation-induced cytokine, OPGL, ODF, Osteoclast differentiation factor, Tumor necrosis factor ligand superfamily member 11, Receptor activator of nuclear factor kappa B ligand, RANKL, Osteoprotegerin ligand, CD254 antigen, sRANKL, sOdf, hRANKL2. |
| Introduction | RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. |
| Description | sRANKL Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 176 amino acids and having a molecular mass of 20006 Dalton. CD254 is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | The protein was lyophilized from a concentrated (1mg/ml) solution containing 10mM Tris, pH-7.5. |
| Solubility | It is recommended to reconstitute the lyophilized sRANKL in sterile 18MΩ-cm H2O at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability | Lyophilized TNFSF11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution sRANKL should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity | Greater than 98.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino acid sequence | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Lys-Ala-Met. |
| Biological Activity | The activity is determined by its ability to induce osteoclast formation in RAW264.7 cells using a conc. of 5.0-10.0 ng/ml corresponding to a specific activity of 100,000-200,000 Units/mg and by dose dependant stimulation of IL-8 production in human PBMC. |
| References | Title:Cathepsin K Expression and Activity in Canine Osteosarcoma. Publication: Article first published online: 15 DEC 2011 DOI:10.1111/j.1939-1676.2011.00834.x Copyright © 2011 by the American College of Veterinary Internal Medicine. Link:http://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2011.00834.x/full |
| Usage | Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
手機(jī)版：sRANKL Human
- 中喬新舟限時(shí)促銷：買細(xì)胞就送支原體檢測(cè)試劑盒
- 華威中儀試劑盒年末限時(shí)優(yōu)惠來(lái)襲，儲(chǔ)值享好禮
- 美德聲推出新品重組細(xì)胞系用于生產(chǎn)單克隆血型試劑
- 百螢小麥胚芽凝集素探針染料8折優(yōu)惠，買即贈(zèng)鼠標(biāo)墊
- 上�；菡\(chéng)生物成為安普未來(lái)恒溫?cái)U(kuò)增試劑盒代理商
- 雙11科研狂歡促銷，逐典攜手埃澤思下單滿額雙重好禮
- MCE 第三屆細(xì)胞攝影大賽圓滿落幕，評(píng)選結(jié)果公布
- MCE教師節(jié)直播:細(xì)胞凋亡的機(jī)制、標(biāo)志物與檢測(cè)方法
- 大鼠肺泡巨噬細(xì)胞(NR8383)培養(yǎng)要點(diǎn)
- 干細(xì)胞誘導(dǎo)生成類器官的工藝要點(diǎn)淺析
- 細(xì)胞復(fù)蘇的原理、實(shí)驗(yàn)步驟及注意事項(xiàng)
- 10個(gè)獲批干細(xì)胞新藥IND及細(xì)胞療法應(yīng)用案例分享
- 寵物干細(xì)胞行業(yè)技術(shù)服務(wù)體系及在治療中的應(yīng)用
- 《人臍帶間充質(zhì)干細(xì)胞治療膝骨性關(guān)節(jié)炎臨床應(yīng)用指南》內(nèi)容及適用范圍
- 免疫B細(xì)胞的分類、活化機(jī)制、主要功能及在疾病治療中的應(yīng)用
- 自然殺傷細(xì)胞（NK細(xì)胞）的功能及培養(yǎng)流程
Copyright(C) 1998-2025 生物器材網(wǎng) 電話：021-64166852;13621656896 E-mail：info@bio-equip.com