product information

background
 

Scribble human homologue, hScrib, is a substrate of ubiquitin-mediated degradation by human papillomavirus E6 and the E6AP ubiquitin-protein ligase. hScrib is localised to the basolateral regions of the epithelial cell line MDCK.  The mammalian homolog of Scribble has a primary structure and subcellular localization similar to that of its fly homolog, but its function remains unknown. hScrib can have a potential role in the suppression of mammalian tumorigenesis. Alternative name: Protein LAP4

immunogen
 

GST tagged C-terminus of hScrib Q14160 including PDZ3 and 4 domains

antibody format
 

rabbit;

polyclonal;

serum;

lyophilized

quantity
 

100 µl

- for reconstitution add 100 µl of sterile water

storage
 

store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

tested applications
 

Western blot (WB)

related products
 

to be added when available

additional information
 

to be added when available

application information

recommended dilution
 

1: 5 000 with standard ECL (WB)

expected | apparent MW
 

175 kDa

confirmed reactivity
 

human

predicted reactivity
 

human

not reactive in
 

no confirmed exceptions from predicted reactivity known in the moment

additional information
 

reactivity showed on dilluted human cell culture extracts

selected references
 

to be added when available

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